this is an exam paper you need to answer one question out of the 3 only
Answer ONE question in this section.
1. Evaluate the use of SGLT inhibitors in the management of cardio-renal
disorder. Your answer should include molecular and cellular mechanisms of
cardio-renal disease, the significance of renal damage and therapy, and the
rationale and mechanisms of action of SGLT inhibitors.
2. Using only pre-clinical and clinical trial data, evaluate how a named xenobiotic
can cause toxicity and damage in the heart. Your answer should include
molecular mechanisms of toxicity and pathogenesis of specific heart disease.
3. Evaluate in detail the rationale of PCSK9 inhibition as a strategy for lowering
lipids. Your answer should include the discovery of PCSK9, mechanisms of
action of named PCSK9 inhibitors and preclinical/clinical data.